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Cellular GSSG accumulation, as opposed to GSH reduction, rendered hepatocytes susceptible to TNF cytotoxicity Increased GSSG/GSG ratios in response to H 2 O 2 exposure can stem from both GSH reduction and GSSG accumulation (data not shown)
To put this in perspective, the antihypertensive medication lisinopril typically reduces systolic blood pressure by 8-10 mmHg
Similar content being viewed by others Subjects Introduction A prominent feature of biological aging is a progressive decline in antioxidant defense mechanisms, which are crucial to protecting cells and tissues from many oxidative, chemical and pathological stresses 1,2,3,4,5,6
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