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Even moderate alcohol intake can substantially reduce the caloric deficit necessary for weight loss, potentially explaining poor treatment response in otherwise adherent patients

a , GRID hotspot analysis of the binding mode of peptide 5 showing the overlap of the Cap 1 , X 2 and X 3 groups of peptide 5 with lipophilic regions of the GLP-1R

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The theory is that this keeps your body sensitive to the peptide and helps you lock in your progress, though this hasn't been proven