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Animal data suggests NSAIDs may blunt some of the healing signals that BPC-157 is proposed to potentiate, specifically COX-2-mediated prostaglandin pathways that contribute to tissue remodeling

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Higuero T, Abramowitz L, Castinel A, Fathallah N, Hemery P, Laclotte Duhoux C, Pigot F, Pillant-Le Moult H, Senjoux A, Siproudhis L, Staumont G, Suduca JM, Vinson-Bonnet B

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This smaller segment of the molecule retains strong anti-inflammatory properties without affecting hormone levels