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Tirzepatide was associated with larger decreases in glycated hemoglobin and body weight compared to Semaglutide in head-to-head analysis (Del Prato, The Lancet )
Wegovy (semaglutide) activates one receptor (GLP-1), while Zepbound (tirzepatide) activates two (GIP and GLP-1)
NICE Technology Appraisal (TA664) recommends liraglutide for managing overweight and obesity as part of specialist weight management services for appropriate patients who have not achieved adequate weight loss with lifestyle interventions alone
These processes, in turn, decrease insulin-stimulated IRS-1/IRS-2 tyrosine phosphorylation, PI3K activation and downstream insulin signaling that then induces IR in muscles and livers
Pinelli NR, Moore CL, Tomasello S
