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The hypothalamic projection involves noradrenergic neurons of the locus coeruleus (LC) and serotoninergic neurons of the dorsal and median raphe nuclei (DR), which pass through the lateral hypothalamus and reach axons of the histaminergic tubero-mamillary nucleus (TMN), together forming a pathway extending into the forebrain, cortex and hippocampus

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Mov Disord 14 : 545550 Walshe JM (1982) Treatment of Wilson's disease with trientine (triethylamine tetramine dihydrochloride)

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