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eNAMPT Is Localised to Areas of Cartilage Damage in Patients with Hip Osteoarthritis and Promotes Cartilage Catabolism and Inflammation
22 Based on the favorable bioavailability of the amide, N-acetylcysteine amide (NACA), over the acid, NAC, 23 and likely its methyl ester, 24 the pursuit of NACA therapy for treatment of HCCAA is warranted
In addition, small molecule inhibitors including SLC7A11 inhibitor HG106 and GCLC inhibitor buthionine sulfoximine (BSO) were introduced to investigate their effects on ROS, GSH levels and cellular viability in VRK2-KO and VRK2-KD cells, and the results were consistent with the above knockdown experiment (Fig
1999;40(suppl):S289
2010 Apr 25;10:17
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