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Supporting Research Clinical trials - including three large-scale 68-week studies - have shown that adults without diabetes, when treated with semaglutide alongside a reduced-calorie diet and increased physical activity, achieved significant weight loss compared to placebo groups

Studies on GSTO1-1 also suggested a protective effect of this enzyme on PD, exerted through the inhibition of the active form of interleukin-1 (IL-1 ) which is a critical factor in inflammatory response 47,58

doi: 10.1002/(sici)1096-9861(19990111)403:2 3.0.co;2-5 35 HolstJJ

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Kitzman DW, Brubaker P, Morgan T, Haykowsky M, Hundley G, Kraus WE, et al