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For example, previous studies have shown that APP/PS1 transgenic mice that express the mutated variant of human APP and PSEN1 genes linked to familial AD, namely, the Swedish APP KM670/671NL mutation (APPswe) and PSEN1 L166P mutation, exhibit memory deficits and impaired hippocampal neurogenesis in adulthood [124]
Bentivoglio et al
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