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High gastrointestinal discontinuation rates exceeding 50% across all doses, combined with liver safety signals in early studies, ultimately led Pfizer to discontinue danugliprons development in April 2025
Badaloo, A., Reid, M., Forrester, T., et al
We also observed the ability of GLP-1(2836) to increase cAMP production through bicarbonate-responsive (i.e., probenicid-inhibited) sAC in human caECs
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