3rd generation glp 1 Comment “Curious” for the deep dive. Retatrutide — a.k.a. “Reta” or “GLP-3” — is being called a future “trillion-dollar drug” and a revolution in fat loss. Retatrutide is a third-generation GLP-1–based drug. ( GLP-3 R (GLP-1 | GIP

The SURMOUNT-5 trial directly compared the two medications and found tirzepatide produced approximately 20 percent weight loss compared to 14 percent for semaglutide

Its also approved for weight management at higher doses under the brand name Wegovy

(PubMed) Bidulescu A, Chambless LE, Siega-Riz AM, Zeisel SH, Heiss G

Synergy with Growth Hormone Because IGF-1 is normally secreted in response to growth hormone (GH) , stacking IGF-1 LR3 with GH secretagogues or GH-releasing peptides (like CJC-1295 or Ipamorelin) enhances both natural and exogenous pathways compounding effects on growth and recovery

doi: 10.1093/carcin/bgn218 158 LeeYMKimMJKimYKimH