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Potential areas of expansion include: Cardiovascular outcomes: A dedicated CVOT, if not already required as a post-marketing commitment, would evaluate whether orforglipron reduces MACE in patients with established cardiovascular disease or high cardiovascular risk, following the precedent set by the SELECT trial for semaglutide
BMJ Open 12(2):e053936
Physicians at UAB Hospital are reporting a sharp increase in emergency room visits linked to GLP-1 medications such as Ozempic and Mounjaro, citing a surge in overdoses and adverse reactions
Blending can damage the liposomes
The sequence of GLP-1 is fully conserved in all mammalian species examined so far
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