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Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and downregulation of bax expression

MC1R activation on melanocytes triggers a signaling cascade through cyclic AMP (cAMP) and the MITF transcription factor, upregulating tyrosinase and other melanogenic enzymes