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1 People included in the trial were aged 45 years with a BMI 27 kg/m 2
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***Metabolic Improvement*** BRP significantly improved glucose tolerance and insulin sensitivity in mice, while simultaneously reducing fasting blood glucose and insulin levels, and alleviating hepatic lipid accumulation
The obesity groups were fed a cafeteria diet with a macronutrient profile of 48% carbohydrates, 11% protein and 41% fat (5004 kcal/kg) 19,20
Consequently, TNBS in 50% ethanol, referred as TNBS+ethanol, was used in the following series of in vivo experiments
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