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These microbiota-derived agents can inhibit Gram-negative pathogens through diverse mechanisms, such as direct bactericidal activity, modulation of host immune responses, and promotion of colonization resistance
Mechanistically, TMAO disrupts myocardial calcium homeostasis through two distinct pathways: direct elevation of intracellular Ca 2+ concentration and promotion of SERCA2a (sarco/endoplasmic reticulum Ca 2+ -ATPase) autophagic degradation, which attenuates sarcoplasmic reticulum Ca 2+ reuptake capacity (Lei et al., 2025)
All collected samples were subsequently analyzed using ICP-MS
The hypertension segment accounted for a significant market share of 35.2% in 2024
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