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Some researchers report observing initial changes within one to two weeks, while more significant structural changes would be assessed over a full 4-8 week cycle
Autophagy deficiency in neurons results in buildup of ubiquitinated proteins, dystrophy of neural terminals, impairments in synaptic transmission, and eventually, neurodegeneration observed in both neurodegenerative and neurodevelopmental disorders [245, 249, 250]
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Many growth factors such as transforming growth factor (TGF)-, 2 platelet-derived growth factor (PDGF), 3 epidermal growth factor (EGF), 4 and fibroblast growth factor (FGF), 5 as well as interleukin (IL)-1 6 and tumor necrosis factor (TNF), 7 have been evaluated in a wide spectrum of in vivo and in vitro experiments to observe their effects on different elements included in the healing process
doi: 10.3390/ijms19030862 58 Otulak-KozieK.KozieE.LockhartB
