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Calcium homeostasis is maintained through SERCA2a activation to enhance calcium reuptake and restore normal flux, while inhibiting Ca 2+ -dependent calcineurin/calpain/CaMKII activity to prevent calcium overload-induced remodeling (Hedayati et al., 2023)
If confirmed, that mechanism would represent a genuinely novel approach to treating substance use disorders
Do not freeze the injection, as freezing may destroy its active ingredients
Because many people take it for six months or longer (and sometimes long-term to maintain results), its worth considering both short- and long-term costs upfront
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