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(PubMed) Scarpini E, Sacilotto G, Baron P, Cusini M, Scarlato G

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"Polyamine pathway activity promotes cysteine essentiality in cancer cells." Nature Metabolism (2020);03 August 2020 PMID: 32747794 25

Hydroperoxyl radical (HOO()) as a reducing agent: unexpected synergy with antioxidants

While nuclear factor erythroid 2-related factor 2 (NRF2) and CCAAT/Enhancer Binding Protein (CEBP) also contribute to a minor increase in CHAC1 transcription, their roles are less pronounced compared to ATF4 ( FIGURE 4 ATF4 and ATF3 regulate CHAC1 expression by binding to specific sites within its promoter, the ATF/cAMP response element (CRE) at position 267 and the ATF/CRE modifier (ACM) motif at 248