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Despite the fact that in most cases UGTs are responsible for glucuronidation of their substrates, members of the UGT1A subfamily have been found to catalyze glucuronidation of several aminecontaining substrates (chlorpromazine, amitryptyline) (Tukey & Strassburg, 2000)

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Not just weight reduction, but reductions in heart attack, stroke and cardiovascular death. Those findings helped reposition GLP-1s as long-term metabolic therapies rather than short-term fixes