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Primary candidates include patients with type 2 diabetes and established cardiovascular disease, those with multiple cardiovascular risk factors including dyslipidemia, and adults with obesity or overweight with weight-related comorbidities

Best fiber sources for GLP-1: Oats and barley beta-glucan fiber has been specifically shown to raise GLP-1 in multiple clinical trials Legumes (all types) black beans, lentils, chickpeas, split peas Jerusalem artichokes and leeks rich in inulin, a prebiotic fiber that feeds GLP-1-producing bacteria Apples, pears, and berries pectin fiber with strong prebiotic effects Vegetables (especially asparagus, onions, garlic) inulin and FOS fiber Fermented Foods and the Gut-GLP-1 Axis The gut microbiome plays a direct role in GLP-1 regulation

Rios, M

Corbo M, Lunetta C, Magni P, Dozio E, Ruscica M, Adobbati L, Silani V: Free insulin-like growth factor (IGF)-1 and IGF-binding proteins-2 and 3 in serum and cerebrospinal fluid of amyotrophic lateral sclerosis patients

Monotherapy versus Combination Therapy The decision to initiate drug therapy with metformin alone or in combination with another agent is influenced by HbA1C level and health status when diabetes is newly diagnosed