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The glutamate residue is linked through its side-chain carboxyl, giving a gamma-glutamyl bond rather than a standard alpha-peptide bond, which is why the molecule resists most intracellular peptidases and is cleaved chiefly by gamma-glutamyl transpeptidase at the cell surface
The system Xc, a dimer consisting of SLC7A11 and SLC3A2, exchanges glutamate (Glu) out of the cell and cystine into the cell at a ratio of 1:1 [27, 28]
If follow-up has lapsed which is not uncommon several years after surgery patients are encouraged to re-engage with their GP to arrange a nutritional review and, where appropriate, re-referral to the original bariatric unit or a local specialist service
Mini review: promotion of substance abuse in HIV patients: biological mediation by HIV-1 Tat protein
