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Luteolin potentiates the sensitivity of colorectal cancer cell lines to oxaliplatin through the PPARgamma/OCTN2 pathway

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These three mechanisms act synergistically to significantly reduce serum creatinine levels and reduce tubular necrosis in mouse models, effectively improving RIRI

In addition, alterations of function and expression of proteins associated with iron metabolism are increasingly recognized to be pathogenetic factors and potential vulnerabilities of these diseases

However, despite recent progress in understanding the mechanisms of receptor activation, the relationship between peptide sequence and functional activity is not fully understood