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Although TR/GR-null livers generate some of their cysteine through the serine transsulfuration pathway, we here show that most cysteine in TR/GR-null livers comes from a pathway in which pyridoxal-phosphate-dependent cleavage of a carbonsulfur bond in cystine generates cysteine persulfide, which decomposes nonenzymatically into cysteine

Figure 3 Machine learning may help integrate metabolite panels with imaging and clinical data, but it should not obscure biology

While limited evidence supports this, the practice is common

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Decoding ischemic stroke: perspectives on the endoplasmic reticulum, mitochondria, and their crosstalk