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Biosynthesis runs through two ATP-dependent steps, glutamate-cysteine ligase (EC 6.3.2.2) followed by glutathione synthetase
You do not need genetic testing to benefit from active forms, but for individuals who do carry these variants, it can be particularly relevant
Several studies suggest that high-dose oral supplementation (e.g., 1000 to 2000 mcg daily) can be as effective as injections for some patients, but this depends on individual health status
they target slightly different research questions
Discontinuation due to adverse events was about 4% across all dose groups
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