THF plays an important role in DNA synthesis, so reduced availability of THF results in ineffective production of cells with rapid turnover, in particular red blood cells, and also intestinal wall cells which are responsible for absorption
By inhibiting NNMT, 5-Amino-1MQ would in principle preserve more nicotinamide for NAD+ salvage
General guidelines suggest individuals under 150 pounds may start with 50-75mg daily, those between 150 and 200 pounds typically use 75mg daily as a standard protocol, and individuals over 200 pounds may need 75-100mg daily for optimal effects
This article covers the mechanistic differences that determine experimental outcomes, dosing considerations for research protocols, and what the existing clinical data actually supports versus what marketing claims suggest
Folic Acid (Vitamin B9) This vitamin is essential for red blood cell production and DNA repair and production