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He also cautions against use for anyone with severe liver disease or renal failure because these conditions may slow the elimination of PT-141 from the body
For example, exenatide reduces the peak concentration of ethinyl estradiol by 15% to 45%, depending on timing, while liraglutide decreases it by 12%
Individuals with higher starting body weight may experience larger reductions over time as the medication begins to regulate appetite and metabolism
[1] [2] In that trial, diarrhoea was reported in a meaningful proportion of participants, with rates generally higher at elevated doses and during escalation periods
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