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They showed that intestinal NE was reduced but still present in germ-free mice 24
Identification of glucagon receptors in rat brain
Konopleva M, Tsao T, Estrov Z, Lee RM, Wang RY, Jackson CE, McQueen T, Monaco G, Munsell M, Belmont J, Kantarjian H, Sporn MB, Andreeff M
Eli Lillys GLP-1 offering, tirzepatide, launched shortly after (as Mounjaro for T2D in 2022 and Zepbound for obesity in 2023), demonstrated greater HbA1c reduction and up to a 20% placebo-adjusted weight loss
Ostrovsky O, et al
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