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A lighter or leaner body receives more exposure per kilogram and may show a different balance of appetite, heart-rate, and lean-mass effects

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No mutagenicity or teratogenicity has been observed, even at doses 1,000 times higher than those typically used in research

Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice