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[42] This opened the door to the discovery of the glucagon-like peptide-1 receptor and then drugs which target that receptor, known as GLP-1 receptor agonists

Nausea Vomiting Diarrhea Constipation Decreased appetite Injection-site reactions Gallbladder events (cholelithiasis, cholecystitis) reported in some Phase 2 participants Increased heart rate Possible pancreatitis (per GLP-1 class data not specifically reported in retatrutide trials) Frequently asked questions Is retatrutide FDA-approved

Loguhrey et al

doi: 10.3389/fphar.2026.1856307 Received 15 April 2026 Revised 25 May 2026 Accepted 27 May 2026 Published 17 June 2026 Volume 17 - 2026 Edited by Carlos Rodrguez-Nogales, Universidad Complutense de Madrid, Spain Reviewed by Madhusudan Prasad Singh, All India Institute of Medical Sciences, Deoghar (AIIMS Deoghar), India Alessandro Conforti, Nephrology Unit, ASL Roma 4, Italy Updates Copyright 2026 Wu, Lei, Sa, Zhong and Lu

Over time, the associated risk reduction continued to drop: At 7 years, GLP-1 users had an 87 percent lower risk