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The Beers Criteria, a guideline for medication use in older adults, lists NSAIDs as potentially inappropriate due to high risk of GI bleeds and renal failure

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It can also cause mouth ulcers, vision issues, and pins and needles

Without clinical trial data, no evidence-based answer exists

Low-Dose Ketamine Pretreatment Reduces Oxidative Damage and Inflammatory Response Following CO2 Pneumoperitoneum in Rats