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Semaglutide is a specific GLP-1 receptor agonist (GLP-1 RA) a medication that mimics the action of natural GLP-1 but with important modifications: Extended half-life: Semaglutide is engineered to resist degradation by DPP-4, allowing it to remain active in the body for approximately 7 days, compared to just minutes for natural GLP-1

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In the SURMOUNT-1 study, nearly 500 adults with obesity took tirzepatide for 36 weeks