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This gradual escalation prevents overwhelming side effects like flushing, nausea, or headaches that occur when starting at high doses, allows the pituitary to adapt to regular stimulation improving long-term response, and provides opportunity to identify minimal effective dose avoiding unnecessary higher dosing and associated costs

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Weight loss remains the cornerstone of OSA management, but pharmacologic agents that induce significant weight loss and potentially modulate central respiratory pathways may offer added benefit (Figs

De Berardis D, Orsolini L, Serroni N, et al

Meta-analyses also affirm GLP-1RAs benefit in heart failure with preserved ejection fraction (HFpEF) [59]