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It consists of 15 amino acids (a pentadecapeptide) and has been extensively studied in animal models for its tissue-healing and protective properties156

2021;10(14):e020734

Metformin may produce modest weight loss of 4-7 pounds over 6-12 months in patients with Hashimoto's who have concurrent insulin resistance or prediabetes, though it is not FDA-approved for this indication