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Studies in hundreds of participants have found that higher blood levels of 1-methylnicotinamide (a marker related to NNMT activity) correlated with greater NNMT in adipose tissue, and were inversely related to insulin sensitivity

In integrated analysis, metabolite-gene relationships were distinct between pregnancies with and without obesity, and the abundance of lipids were positively correlated with the expression of KDM4D, DTX3 , and NOTCH4 and negatively correlated with the expression of MT_TS1

2015 Mar 15;95(4):702-7

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Proteasome inhibitor-induced apoptosis in CLL is associated with immediate disruption of mitochondrial function