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(12) Nrf2 is a protein that may regulate the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation

While B12 injections are typically safe, some people might experience slight swelling or irritation at the injection site

In particular, up-regulation of the transcripts for the rate-limiting enzyme of the TCA cycle, 2-oxoglutarate dehydrogenase (OGDH), and for the TCA-cycle-affiliated proteins, such as subunits of pyruvate dehydrogenase (PDH) and branched chain 2-oxo acids dehydrogenase (BCODH) is observed

Dec 2016;62(6):387-395

It helps in reducing redness and dark spots, and low levels may cause dryness or premature aging