TP53 Mutant Acute Myeloid Leukemias comprise Stem-like Cell Enriched Cellular Hierarchy and are Vulnerable to Targeted Protein Degradation of c-MYC
The rate-limiting step in extracellular GSH catabolism is controlled by -glutamyltransferases (GGTs), which cleave the -glutamyl bond in GSH to release glutamate and dipeptide cysteinylglycine
Biomed Chromatogr 14:351372 Rauha JP, Vuorela H, Kostiainen R (2001) Effect of eluent on the ionization efficiency of flavonoids by ion spray, atmospheric pressure chemical ionization, and atmospheric pressure photoionization mass spectrometry
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This observation aligns well with the experimental IC50 values, where ligand TMQ057 exhibited the lowest inhibitory potency, suggesting that it had weaker binding interactions with the protein