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NICE and British Society for Haematology guidelines recommend: Initial treatment with hydroxocobalamin (the preferred form in the UK) via intramuscular injection For patients without neurological involvement: 1 mg IM three times a week for 2 weeks For patients with neurological involvement: 1 mg IM on alternate days until no further improvement Maintenance: 1 mg every 3 months for patients without neurological involvement

If this assumption turns out to be correct, GSH-related biological reactions should not follow the concentration dependence predicted by the Nernst equation, but comply with the kinetic characteristics of the enzymes involved (Floh, Statements Author contributions All authors jointly wrote the manuscript

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This mechanism helps explain why healing benefits often extend for weeks or months beyond the administration period

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