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These peptides initially stimulate hormone release but subsequently suppress gonadotropin production through receptor downregulation, effectively reducing sex hormone levels that fuel certain cancers

Long et al., 2024), including the NADPH/FSP1/CoQ10 pathway, the dihydroorotate dehydrogenase (DHODH) pathway, the GTP cyclohydrolase 1 (GCH1)/tetrahydrobiopterin (BH4)/dihydrofolate reductase (DHFR) pathway, the membrane-bound O-acyltransferase 1/2 (MBOAT1/2) pathway, the peroxiredoxin 6 (PRDX6) pathway, and the 7-dehydrocholesterol (7-DHC) pathway

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Both endotoxin replicates passed at an assay sensitivity of 0.05 EU/mL or lower, and the PCR screen returned no detectable microbial DNA