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During weeks 4-12, the period of most aggressive appetite suppression: 23% of participants reported average daily intake under 1,000 calories 41% reported skipping at least one full meal per day, three or more days per week 67% reported inability to finish "normal" portion sizes 8% required temporary dose reduction due to intake dropping below 600 calories for more than 48 hours The trial protocol required a minimum intake of 1,200 calories per day for women and 1,500 for men

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Surgery, anesthesia, and opioid pain medications all slow GI transit

Ogata, S., Misumi, Y., Tsuji, E., Takami, N., Oda, K., and Ikehara, Y