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It is a reflection of obesity as a chronic condition requiring ongoing management rather than a temporary intervention

Exenatide was approved by the US FDA in 2005 and by the European Medicines Agency (EMA) in 2006

Although DSM-5 diagnosis is defined through multiple behavioral criteria encompassing impaired control, social dysfunction, continued use despite harm, and tolerance or withdrawal, converging clinical and preclinical evidence indicates that the core pathological feature of SUDs is the progressive loss of control over intake (O'Brien, 2005)