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While results from mouse models have failed to provide a definitive answer to settle the contributory role of TJ integral (and associated) proteins in regulating mucosal barrier dysfunction and inflammation, they have definitively clarified the critical role of these proteins in the maintenance of gut epithelial homeostasis

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Directly comparing healthy young (N=93, ages 18 to 42 years) and older (N=62, ages 53 to 70 years) men, another RCT found that supplementation with increasing doses of EPA-rich oil (that also contained some DHA) for 12 weeks had differential effects on immune parameters (44)

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