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In order to determine the impact of elevated GSH on artemisinin potency, we pre-treated artemisinin resistant (Cam3.II C580Y ) and sensitive (Cam3.II REV ) parasites with N-acetyl cysteine (NAC), a precursor for GSH de novo synthesis 46 and measured sensitivity to 700 nM of DHA by RSA
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Their mechanism involves enhancing mitophagy, suppressing NLRP3 inflammasome activation in hepatocytes, and modulating key metabolic regulators
J Psychosom Obstet Gynecol
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