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They warn that the lack of rigorous clinical trials and standardized protocols raise serious safety concerns, including the risk of hepatotoxicity (liver damage caused by chemicals) and allergic reactions like anaphylaxis

As a consequence, a loss of lipoic acid-dependent enzymatic activity caused by defects in endogenous lipoic acid synthesis (see Deficiency) cannot be rescued by the provision of exogenous lipoic acid (5)

The copper complex itself contributes to the taste perception

This is where the comparison gets interesting and where supplementation strategy matters a lot