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The date of filling the first prescription was defined as the index date

The effects of long-term oral benfotiamine supplementation on peripheral nerve function and inflammatory markers in patients with type 1 diabetes: a 24-month, double-blind, randomized, placebo-controlled trial

The gold standard for establishing cause-and-effect relationships is a randomized controlled trial

While GGT5 and GGT1 share 40% of the amino acid sequence (22), GGT5 is not as active in hydrolyzing GSH, GSSG and leukotriene C4 as GGT1 is (29)

This timing allows peak tissue levels to coincide with the first sleep cycle when growth hormone release and collagen synthesis are highest