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While such reluctance is understandable, it would be a mistake to allow the FDAs disastrous history of weight loss drugs to make us cynical rather than skeptical

Available from: Chhimpa N, Singh N, Puri N, Kayath HP The Novel Role of Mitochondrial Citrate Synthase and Citrate in the Pathophysiology of Alzheimers Disease

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The mechanism of action involves several key effects: Enhanced insulin secretion from pancreatic beta cells in a glucose-dependent manner, which helps lower blood glucose levels without causing hypoglycaemia when glucose levels are normal Suppression of glucagon release from pancreatic alpha cells, reducing hepatic glucose production Delayed gastric emptying , which slows the rate at which food leaves the stomach and enters the small intestine Increased satiety through central nervous system effects, leading to reduced appetite and food intake The delayed gastric emptying effect is particularly relevant in the perioperative setting