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Although the permeability value of targeted nanocarriers were lower in case of BBB models on the inserts with 0.4 m pore size membranes, the significant difference between the non-targeted and targeted groups remained the same and the penetration of marker molecules across the BBB model on inserts with 3 m pore-size membranes or 0.4 m pore-size membranes were also similar

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Vascular congestion (yellow arrow), dense cellular infiltration (black star), hemorrhage (black arrow), and intense fibrosis (black arrowhead) were observed in the stromal tissue