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Injectable administration is hypothesized to provide systemic distribution, but human pharmacokinetic data for this route does not exist

Zhao J, Dong X, Hu X, et al

Aldose Reductase Inhibitors Aldose reductase inhibitors (ARI) work by blocking the enzyme aldose reductase in the polyol pathway, which under hyperglycemic conditions converts excess glucose into sorbitol, a sugar alcohol that accumulates in nerves and causes osmotic stress, oxidative damage and impaired nerve function [116]

Crotonyl-CoA can also serve as the substrate for the post-translational modification of lysine residues, a process termed protein crotonylation

Pro Tip Create a separate consent form for each injectable treatment you offer