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Both were developed at the University of Arizona in the 1980s and 1990s

*Correspondence: Vincenzo Triggiani, [email protected] This article was submitted to Clinical Diabetes, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

In contrast, glucagon raises blood glucose by promoting the release of glucose from the liver

Its necessary for the production of nitric oxide, a signaling molecule thats needed for a variety of bodily processes and functions, including blood flow regulation, mitochondrial function, and cellular communication