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In fact, lipotoxicity has been linked to the HFpEF pathophysiology
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4 However, a 6-month placebo-controlled RCT in 54 non-smoking adults documented dose-dependent increases: at 1,000 mg/day, GSH levels rose 30-35% in erythrocytes, plasma, and lymphocytes, and 260% in buccal mucosal cells, with effects reversing after supplementation was stopped
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Samples were then centrifuged at 15,000 g for 5 min to pellet cellular debris, and the supernatant was collected
But these data gaps further underscore the need to study this population, as currently, there is "limited or no clinical guidance" on the use of GLP-1s prior to conception, the commentary authors wrote
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