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Ozempic's influence on weight loss is twofold : it targets the hunger centers in the brain, particularly in the hypothalamus, reducing hunger, appetite, and cravings
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What they found (summary): MC1R: melanogenesis, pigmentation, anti-inflammation MC2R: ACTH receptor in the adrenals (Melanotan II does not act) MC3R: energy, cardiovascular function, anti-inflammation MC4R: appetite (central control), sexual function, autonomic regulation MC5R: exocrine glands (sebaceous, lacrimal, salivary) Mutations in MC4R are the most common monogenic cause of obesity in humans Why it matters: Cones review article is the reference article for all of melanocortin pharmacology
GLP-1 inhibitor drugs, originally developed for managing type 2 diabetes, mimic hormones that regulate blood sugar levels, which can help decrease appetite and lower calorie intake
