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Under oxidative stress, accumulation of ROS can activate pathways such as the JNK and the p53, further inducing autophagy, which helps clear damaged organelles, reduces oxidative damage, and protects cell survival [256]

105 KerrJRGoughJRichardsSCMainJEnlanderDMcCrearyMet al

Yang et al., 2022b)

In placebo-controlled trials, cholelithiasis was reported in 1.5% and 0.4% of patients treated with Ozempic injection 0.5 mg and 1 mg, respectively, and not reported in placebo-treated patients